The absence of FMRP protein causes an unregulated protein production in the synapses and in particular we think that the reduced concentration of PSD-95 mutations cause structural.
The journal Molecular Cell published a new research to discover some of the key mechanisms underlying fragile X syndrome. In this disorder, which is the form of inherited mental impairment, more widespread, the absence of FMRP protein causes an unregulated production of protein at the synapse, which in turn undergo structural changes leading to deficits in learning and memory, and also you hyperactivation of signaling pathways established.
The professor of cell biology and neurology at Emory University School of Medicine Bassella Gary and his team have focused particularly on the protein PSD-95, which seems to have a strong role in the link between the signaling molecules of neuronal synapses.
“The neurons need to produce new proteins required for synapses to occur in certain processes of memory and thought. From what it seems, FMRP has evolved to take advantage of the microRNA to control protein synthesis at synapses. We think that no longer able to synthesize the PSD-95 is important in the production of a mutation of the synapse,” said Bassella.
