Under the title “Statins as Neuroprotectants: A Comparative In Vitro Study of lipophilicity, Blood-Brain-Barrier Penetration, Lowering of Brain Cholesterol, and Decrease of Neuron Cell Death” article published in Journal of Alzheimer’s Disease , Neuron BioPharma shows results neuroprotective capacity of statins that are currently in the market among which is the statin simvastatin business with the best features to prevent neurodegeneration .
The above study concludes that statins Monacolin derived from J (statins natural and semi-synthetic, such as simvastatin and lovastatin) are the best candidates for the prevention of neurodegeneration, due to its high potential to cross the blood brain barrier. The reduction of cholesterol in neurons, the high profile of biosecurity and protection against Alzheimer-type damage.
Find protein that modulates the communication between neurons:
In the latest issue of the journal Neuron was published the work that researchers have made Neuroscience Institute , Joint Center CSIC and Universidad Miguel Hernández de Elche, which is revealed the discovery of a protein called SNAP25 , known to be connected the process of release of neurotransmitters, chemical messengers through which neurons communicate.
The study authors have determined that this protein plays a key role in the regulation and stabilization of neuronal or synaptic interaction (point where neurons exchange information), to adjust the intensity of neuronal transmission so long.
The team has managed to describe the protein SNAP25 interacts with kainate receptors and is key to their turnover in the synapse, so that the breaking of this interaction leads to accumulation of membrane receptors and increases neuronal communication.
This finding may be critical to the future development of therapies for the treatment of epilepsy and neurodegeneration.
