Discovered the molecule that “off” neurons
New antidepressant drugs could be created thanks to the discovery of MKP-1 protein that plays a key role in the onset of depressive symptoms.
Thanks to research conducted by Yale University, it was discovered that a protein, MKP-1, functions as a switch for MAPK, which is crucial for the survival and proper functioning of neurons.
The study of the American University, conducted in 21 depressed patients died and 18 healthy subjects, showed that the amount of MKP-1 in the brain of depressed is twice that in healthy individuals, the molecule, which in turn switches off the MAPK that encourages the development of depressive symptoms. In animal tests it was observed that inactivating the protein in the brains of mice, they became immune to stress, and conversely, hyperactivity in the molecule, the animal began to show symptoms of depression.
Depression is a disease that causes symptoms of varying severity, so the drugs are effective only about 60% of patients, this research raises hopes in the production of a new class of drugs. The research was published in Nature Medicine.
