Discovered a way to regulate angiogenesis
In the future you can create treatments for diseases of the retina through the regulation of VEGF protein that controls angiogenesis.
Researchers at Cincinnati Children’s Hospital Medical Center have discovered that you can reverse the biological processes that take up the myelocytes of the immune system to regulate angiogenesis.
The study, conducted by the Visual Systems Group, Division of Ophthalmology, was conducted on cell cultures and mice: the retinas of mice developing in the postnatal period, using the network of Wnt signaling, a protein essential in embryonic development and in tumor formation.
The network involves Wnt signals from the gene Flt1 in turn, synthesizes a protein that VEGFR1 receptor (1 vascular endothelial growth factor) capable of blocking vascular development after being linked with the growth factor VEGF. In this way the expression of Flt1 can be decreased to increase the concentration of VEGF, resulting in increased angiogenesis, or by increasing the expression of the VEGF gene inhibits angiogenesis and then crashes.
Richard Lang, Director of the Visual System Group explained: “For now we have been able to demonstrate how this path is used by the Molecular myelocytes to regulate angiogenesis, the modulation in the future of this street, will enable the development of new therapies for repair of damaged tissues, and the progression of retinal diseases”. The research data were published in Nature.
