A non-steroidal medication to block spermatogenesis
Found a drug able to prevent the biochemical pathway of retinoic acid receptor molecules which are metabolites of vitamin A, the lack of which causes male sterility. In the journal Endocrinology is published study to test the efficacy of a drug that could act as non-steroidal male contraceptive.
The study was conducted on laboratory mice and has been shown that administering low doses of this drug that interferes with retinoic acid receptor, spermatogenesis stops and then return to normal levels within hours after the stop of the administration.
The ligands of retinoic acid are metabolites of vitamin A, the privation of which can cause male infertility, in fact, for some time, he was aware of the fact that interfering with the way of retinoid receptors could alter the production of sperm.
The research, led by Debra J. Wolgemuth, will develop new non-steroidal drugs that do not present side effects such as prostate hyperplasia, decreased libido, and cardiovascular risks.